Sialic acid supplementation ameliorates puromycin aminonucleoside nephrosis in rats
نویسندگان
چکیده
منابع مشابه
Osteopontin in chronic puromycin aminonucleoside nephrosis.
Increased expression of osteopontin (OPN) associated with interstitial monocyte infiltration has been demonstrated in the early phase of a variety of experimental renal diseases. Whether these changes occur in the chronic phase of progressive glomerular disease is unknown. Chronic puromycin aminonucleoside nephrosis (PAN) was induced in 16 rats by the injection of a single bolus of PA into the ...
متن کاملMitochondrial dysfunction in focal segmental glomerulosclerosis of puromycin aminonucleoside nephrosis.
Focal segmental glomerular sclerosis (FSGS) is a major renal complication of mitochondrial (mt) cytopathies. The present study was designed to investigate the possibility of mtDNA lesion accumulation in podocytes, which are a primary pathogenic site of FSGS, during the development of glomerulopathy in puromycin aminonucleoside nephrosis (PAN). Two renal pathological phases of PAN, nephrosis pha...
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BACKGROUND Yi Qi Qing Re Gao (YQQRG) formula is a traditional Chinese herbal medicine used to treat chronic nephritis. This study was designed to evaluate the underlying mechanism in the use of YQQRG formula to treat nephrosis induced by puromycin aminonucleoside (PAN). METHODS Thirty-six male Wistar rats were randomly divided into 3 groups of 12 rats each: a sham group, a vehicle-treated PAN...
متن کاملUltrastructural study on nephrin expression in experimental puromycin aminonucleoside nephrosis.
BACKGROUND Nephrin is a recently identified protein that is a key component of the slit diaphragm. This protein may play a crucial role in maintaining the glomerular filtration barrier, and mutations in the gene for nephrin reportedly lead to congenital nephrosis. However, the expression of nephrin in acquired glomerular disease has not yet been fully clarified. To address this issue, we analys...
متن کاملUltrastructural study on nephrin expression in puromycin aminonucleoside nephrosis
Background. Nephrin is a recently identified protein that is a key component of the slit diaphragm. This protein may play a crucial role in maintaining the glomerular filtration barrier, and mutations in the gene for nephrin reportedly lead to congenital nephrosis. However, the expression of nephrin in acquired glomerular disease has not yet been fully clarified. To address this issue, we analy...
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ژورنال
عنوان ژورنال: Laboratory Investigation
سال: 2015
ISSN: 0023-6837,1530-0307
DOI: 10.1038/labinvest.2015.78